Today, November 3^rd, is One Health Day. According to the One Health Commission, “One Health Day answers the urgent need for a One Health trans-disciplinary approach towards solving today’s critical global health challenges.” At VetStem, we have seen this idea of “one health” in action with the creation of our human company, Personalized Stem Cells, Inc.

Personalized Stem Cells (PSC) was formed in 2018 to bring legitimate stem cell therapies to people. PSC used all of VetStem’s animal data to receive approval for two FDA approved stem cell clinical trials. The first clinical trial was for knee osteoarthritis in people, a condition that numerous dogs have received VetStem Cell Therapy for. The second clinical trial utilized VetStem’s intravenous injection data to receive approval to treat COVID-19 patients. Both clinical trials demonstrated solid safety and preliminary efficacy.

Moving forward, PSC plans to pursue an additional clinical trial for knee osteoarthritis, a traumatic brain injury (TBI) trial, and more! Additionally, PSC has the ability to bank stem cells for potential future use, much like VetStem’s StemInsure program. There are a few different programs through the FDA that may allow patients to access their stem cells.

But One Health has worked both ways for us. Interestingly enough, the success of the COVID-19 trial gave us the idea to use stem cells in the treatment of Elephant Endotheliotropic Herpesvirus (EEHV). EEHV is a lethal viral infection that can cause a highly fatal hemorrhagic disease in elephants. VetStem has provided stem cell doses to several zoos in the United States who had elephants with EEHV and has gathered some promising data.

All of that is to say that at VetStem, we know a thing or two about One Health and we’re happy to bring awareness to this cause.  

National Cat Day is fast approaching, and we never miss an opportunity to talk about VetStem Cell Therapy for cats. While stem cells are primarily used for orthopedic conditions, many veterinarians have used VetStem Cell Therapy to help treat and control symptoms associated with diseases such as kidney disease, gingivostomatitis, and inflammatory bowel disease.
All three of these diseases are prevalent in cats and have limited treatment options.

Stem Cells for Kidney Disease

Kidney disease is one of the most common causes of sickness and death in cats. Common symptoms can include weight loss, lethargy, variable appetite, and poor coat quality. Some cats may also drink and urinate more, vomit, or have diarrhea.Unfortunately, treatment options for cats with kidney disease are limited and can be costly.

The good news is, based upon our own data as well as the data of others, we believe that stem cells may help improve the symptoms and quality of life in some cats with kidney disease. In fact, a review of a small number of feline patients treated with VetStem Cell Therapy showed that blood kidney values were slightly to moderately improved after treatment. Owners and veterinarians have also reported improved appetites, weight gain, and increased energy in cats treated with VetStem Cell Therapy.

Stem Cells for Gingivostomatitis

Gingivostomatitis is another debilitating condition found in cats. It is characterized by chronic inflammation of the gums, which can lead to inappetence, reduce grooming, and weight loss. Unfortunately, there is no cure for this disease. Common treatments include lifelong medical management with antibiotics, steroids, and pain medications and/or full mouth teeth extractions.

A recent clinical study demonstrated that intravenous administration of adipose (fat) derived stem cells could ameliorate the clinical signs of gingivostomatitis. Additionally, veterinarians and cat owners have reported an improvement in symptoms and quality of life in cats treated with VetStem Cell Therapy.

Stem Cells for Inflammatory Bowel Disease

Inflammatory Bowel Disease (IBD) is an intestinal disorder that affects both cats and dogs. It is characterized by inflammation of the intestines and can cause vomiting, diarrhea, reduced appetite, and weight loss. It is important to note however, that these symptoms can be indicative of several conditions including feline lymphoma. Since VetStem Cell Therapy is contraindicated in pets with cancer, it is essential to rule this out before pursuing treatment with stem cells.

Multiple cats have received VetStem Cell Therapy for IBD (dogs too!). And we have had reports from veterinarians and owners regarding the improvement of their patients and pets after treatment with stem cells. Additionally, in a recently published paper, 5 out of 7 IBD cats that were treated with stem cells significantly improved or had complete resolution of symptoms, whereas the 4 control cats had no improvement.

If you think your cat may benefit from treatment with VetStem Cell Therapy, speak to your veterinarian or contact us to receive a list of VetStem providers near you.

We spent the better part of last week attending two different veterinary conferences. We love attending these shows as they are a great way to meet with existing and potential clients to talk all things regenerative veterinary medicine. They allow us the opportunity to speak to and educate veterinarians and veterinary technicians from all over the country about VetStem Cell Therapy and how they can implement this therapeutic modality in their practice.

The first part of the week was spent in Atlantic City for the Fetch Coastal veterinary conference. This is a smaller group consisting primarily of small animal veterinarians. Many showed interest in regenerative medicine and our platelet-rich plasma options. Fetch hosts multiple shows throughout the U.S. We attended Fetch DVM360 in Kansas City in August and will attend Fetch Long Beach later this year.

Over the weekend, the team was in Memphis for the annual American Association of Feline Practitioners conference. AAFP is a great show with tons of enthusiastic cat vets. Many veterinarians at this conference show interest in our clinical research programs, such as inflammatory bowel disease, gingivostomatitis, and renal disease, as these conditions tend to be prevalent in cats and have limited treatment options.

If you missed us at these shows, don’t worry! Show season is not over yet! You can find VetStem at the American Association of Equine Practitioners (AAEP) conference and Fetch Long Beach in late November/Early December. And we will of course be back in Las Vegas in February for the Western Veterinary Conference.

October 11th was World Pet Obesity Awareness Day. Obesity is a preventable disease that can cause or exacerbate serious health conditions in pets. Unfortunately, in recent years, pet obesity has been declared an epidemic.

According to the Association for Pet Obesity Prevention, in 2022 59% of dogs and 61% of cats were classified as overweight or obese. In a similar report from Banfield, 1 out of every 3 dogs and cats are overweight and the numbers have continued to go up over the last decade. There are a number of factors that have contributed to the rise in pet obesity rates. These include lack of exercise, genetics, misconceptions about what is considered overweight, specific diseases, as well as overfeeding.

Unfortunately, obesity can cause or exacerbate several serious health conditions such as diabetes, heart disease, and osteoarthritis. A separate report from Banfield concluded that osteoarthritis (OA) has been on the rise over the past ten years with a 66% increase in dogs and a150% increase in cats. These statistics make sense given that obesity has also been on the rise.

The link between obesity and osteoarthritis is an unfortunate vicious cycle: Weight gain causes more wear and tear on your pet’s joints, leading them to be less active and potentially gain more weight. If weight is not lost, the cycle will continue. Furthermore, reduced activity often leads to more stiffness and pain. As we discussed in last week’s blog, regular, low-impact exercise tailored to your dog’s breed and physical abilities may reduce the severity or even delay the onset of osteoarthritis.

If you are unsure if your pet is overweight, it may be a good idea to speak with your veterinarian. Veterinarians are trained to assess your pet’s Body Condition Score or “BCS” (see BCS charts for Dogs and Cats to learn more). In addition to increasing controlled exercise, calorie control is also essential. Your veterinarian can help create a diet plan specific to your pet’s needs. Maintaining an ideal body weight is crucial in minimizing discomfort related to osteoarthritis.

The first week of October is National Walk Your Dog Week and we’ll take every opportunity to share the benefits of walking! According to the website, “Walk Your Dog Week aims to improve the health and wellbeing of America’s dogs.” Walking has many benefits for our canine friends such as providing mental stimulation and an outlet for their energy. Perhaps more importantly, walking can benefit a dog’s joint health as well.

If you follow our blog, you’re probably familiar with the statistic that approximately 1 out of every 5 dogs is diagnosed with osteoarthritis (OA) in their lifetime. Thus, it’s important that we take care of our dogs’ joints from an early age. While there are several ways to support a dog’s joints, studies have found that regular, low-impact exercise, such as walking, can support joint health in dogs with and without OA.

There are several ways in which walking benefits a dog’s joints. One benefit of walking is weight loss or maintaining an ideal weight. Like with people, regular physical exercise can contribute to reaching or maintaining a healthy weight. When dog’s are at an ideal weight, there is less stress on their joints and therefore less wear and tear.

Additionally, walking can help to strengthen the muscles and supporting soft tissue structures around the joints to promote increased joint stability. This kind of movement can also improve joint fluid circulation, which is beneficial to maintaining healthy joint cartilage. With all of these benefits combined, walking has shown to delay the onset and/or reduce the symptoms of OA in dogs.

Of course walking is not a foolproof method to stopping or curing OA altogether. Your veterinarian can offer advice in terms of supplements and other ways to support your dog’s joint health. Additionally, VetStem Cell Therapy has shown to reduce pain and lameness associated with arthritis in dogs, thereby leading to a better quality of life.

If you think your pet may benefit from treatment with VetStem Cell Therapy, speak to your veterinarian or contact us for a list of VetStem providers in your area. And in the meantime, how about going for a walk to celebrate National Walk Your Dog Week!

As we wrap up Animal Pain Awareness Month, we wanted to share a VetStem Cell Therapy success story. As you may remember from last week’s blog, stem cells have the ability to directly modulate pain, thereby leading to increased comfort and an improved quality of life. This particular patient was treated by the President-Elect of the International Veterinary Academy of Pain Management, Dr. Douglas Stramel. Dr. Stramel, who owns and practices at Advanced Care Veterinary Services, is the first and only Certified Veterinary Pain Practitioner in the Dallas/Fort Worth area.

As the President of IVAPM, Dr. Stramel takes pain management very seriously and has made it a primary focus of his veterinary practice. He employs advanced multi-modal pain management protocols including physical therapy, acupuncture, shock wave, laser therapy, and, you guessed it, regenerative medicine. Dr. Stramel has been a longtime user of VetStem Cell Therapy and has treated nearly 50 patients. Thus, when Kim, a German Shepherd and trained agility dog, presented with a partially torn cruciate ligament, he recommended treatment with stem cells.

To begin the VetStem process, Dr. Stramel collected a sample of fat tissue from Kim’s abdomen during a minimally invasive anesthetic procedure. The fat was shipped to the VetStem laboratory where technicians processed the fat to extract and concentrate the stem and regenerative cells contained therein. Three doses were prepared and shipped to Dr. Stramel for injection and the rest of Kim’s cells were put into cryopreservation for potential future use. Approximately 48 hours after the initial fat collection procedure, Kim received an injection of her own stem cells into each knee as well as an intravenous injection.

According to her owner, Kim had a great response to stem cell therapy and her knee is still doing well. She was even able to return to competition! Her owner stated, “Kim’s stem cell injection has provided her an opportunity to live her best life. We decided to change sports, so she now does AKC Rally and UKC Nosework. She continues with rehab to keep her knee in the best possible shape. Her rehab includes cold laser, underwater treadmill, and acupuncture therapy every 2-3 months.”

While stem cells have many mechanisms of action, studies focusing on the ability to directly affect acute and chronic pain have been relatively recent. Stem cells can also down-regulate inflammation and contribute to tissue regeneration, all of which helped to get Kim feeling better.

If you think your pet may benefit from VetStem Cell Therapy, speak to your veterinarian or contact us to receive a list of VetStem providers near you.

We’re back with another pain-themed blog for Animal Pain Awareness Month. This week, we are discussing VetStem Cell Therapy as a means to control pain in pets. While stem cells have many mechanisms of action including the ability to differentiate into many tissue types and stimulate the regeneration of tendon, ligament, and joint tissues, they also have the ability to reduce pain and inflammation.

The ability of stem cells to down-regulate inflammation is important when it comes to pain management. Through cellular communication, stem cells are able to limit inflammatory responses and actually shift from a pro-inflammatory environment to an anti-inflammatory environment. By reducing inflammation, stem cells promote healing and increased comfort.

While a reduction in inflammation can lead to increased comfort, current literature supports that stem cells also have the ability to address both acute and chronic pain directly. Stem cells have shown to secrete pain blocking cytokines (small proteins), which can have opioid-like effects. Interestingly enough, these effects can actually be reversed by Naloxone, an opioid antagonist.

This helps to explain why we consistently hear from pet owners and veterinarians alike that patients treated with VetStem Cell Therapy for things like osteoarthritis or injured cruciate ligaments, experience increased comfort within just days of receiving treatment. By directly decreasing the pet’s pain, their comfort level goes up while the stem cells continue to perform their healing duties.

Thousands of animals have experienced a better quality of life as a result of treatment with VetStem Cell Therapy. Stem cells have the advantage of being a readily available, natural source of anti-inflammatory and pain blocking cells. This can be especially beneficial for cats and some dogs who do not tolerate pain medications well. If you think your pet may benefit from VetStem Cell Therapy, speak to your veterinarian or contact us to receive a list of VetStem providers near you.

For those who missed our last few blogs, September was declared Animal Pain Awareness Month by the International Veterinary Academy of Pain Management (IVAPM). Animal Pain Awareness Month was established to raise awareness and to help veterinary professionals and pet owners recognize and manage pain in animals.

Unfortunately, recognizing pain in our pets is not always easy. Some instances of acute pain are likely to be more obvious, such as pain from an injury or surgical procedure. However chronic pain tends to come on more slowly and thus, we may not recognize the signs for a while. An example of chronic pain is pain from osteoarthritis.

As part of their efforts to educate pet parents about recognizing pain in pets, the IVAPM has a list of the most common signs of pain. They are:

• Decreased activity – Take notice if your animal is not playing as much as usual
• Not going up or down stairs – This could be an early sign of osteoarthritis
• Reluctance to jump onto surfaces – This especially applies to cats
• Difficulty standing after laying down – This is a sign of osteoarthritis
• Decreased appetite – This can signal mouth pain
• Over grooming or licking a particular area – This can be a sign of referred pain

For a more comprehensive list of the common signs of pain in dogs and cats, visit the IVAPM website.

Additionally, they have put together checklists for dogs and cats that can be used to help determine if your pet is in pain.

While September is Animal Pain Awareness Month, it’s a good idea to keep an eye out for these potential signs of pain at all times. If you notice that your pet is exhibiting any of these signs, a trip to your vet may be in order.

As discussed in last week’s blog, September is Animal Pain Awareness Month. Animal Pain Awareness Month was created by the International Veterinary Academy of Pain Management (IVAPM) and is dedicated to raising awareness to help veterinary professionals and pet owners recognize and manage pain in animals. But who is IVAPM? In this week’s blog, we will discuss the IVAPM and their important mission in veterinary medicine.

Who is IVAPM?

The International Veterinary Academy of Pain Management (IVAPM) was founded in 2001 by a group of veterinarians, including one of VetStem’s earliest users and collaborators, Dr. Jamie Gaynor. The organization evolved over the years and today, is led by an active board of directors to provide veterinary pain management education as well as a pain management certification program. The current president of IVAPM, Dr. Douglas Stramel, is also an avid VetStem user.

The IVAPM unites veterinary professionals across all disciplines from around the world to advocate for best practices in the treatment of pain in animals. The organization is committed to encouraging pain management for all animal species through education and advocacy. They also encourage various veterinary organizations to raise public awareness about pain and pain management as it pertains to veterinary patients. IVAPM is the leading forum and educational resource for veterinary professionals and pet owners interested in animal pain prevention, management, and treatment.

IVAPM Pain Management Forum

One of the primary goals of IVAPM is to educate the veterinary community to recognize and treat pain in all species of animals. IVAPM provides continuing education on a variety of topics around the world. As mentioned above, they also provide the only interdisciplinary pain management certification program for veterinary professionals.

In addition to these efforts, IVAPM puts on an annual Pain Management Forum to bring together like-minded veterinary professionals who all advocate for the best practices in the treatment of animals in pain. In both 2022 and 2023, VetStem exhibited and sponsored labs at the Forum. 2024 will bring the third annual Pain Management Forum.

Resources for Pet Owners

The IVAPM does not solely focus on educating veterinary professionals. Pet owners play a key role in both recognizing and managing their pet’s pain. Thus, the IVAPM has several resources for pet owners as well. Through their website, pet owners can search for Certified Veterinary Pain Practitioners and also find various resources to help determine if a pet is in pain.

September is here and as some of you may know, this month is very important in the veterinary world. September has been declared as Animal Pain Awareness Month by the International Veterinary Academy of Pain Management (IVAPM). The goal of this month is to raise awareness and to help veterinary professionals and pet owners recognize and manage pain in animals of all species. As such, each year, we dedicate the entire month of VetStem blogs to the topic.

Pain Management in Pets

Just like people, pain in our pets can lead to a decreased quality of life. By managing an animal’s pain, we not only make them feel better, but we also help them live a happier life. IVAPM works to educate veterinary professionals and pet owners to better understand how to recognize and manage pain in pets and, in doing so, has helped the field of veterinary pain management grow tremendously in recent years.

As the field continues to grow, there have been a great many advances for methods to control pain in animals. Pain medications are no longer the only way to control pain. Several newer and more natural alternatives have become more mainstream in veterinary medicine including things like rehabilitation, acupuncture, and even stem cell therapy. With these advances, veterinarians now have the ability to help several different painful conditions that they struggled with in the past.

Types of Pain in Pets

It is important to note that there are multiple types and causes of pain in animals. Pain can be acute such as pain from a recent surgical procedure or injury. Acute pain is characterized by pain that has come on suddenly or has only been present for a short period of time. Alternatively, chronic pain can be more subtle and likely came on slowly over an extended period of time. An example of chronic pain is osteoarthritis pain.

We can further break this down into types of pain. The three primary classifications of pain are nociceptive, inflammatory, and neuropathic. Nociceptive pain is caused by noxious stimulation such as an injury/physical damage, exposure to chemicals, or exposure to extreme temperatures. As its name suggests, inflammatory pain is caused by acute or chronic inflammation. And lastly, neuropathic pain comes from damage to an element of the nervous system.

Understanding the types and causes of pain in pets can help pet owners recognize when their pet may be in pain and when to seek help from their veterinarian. Pain management is an invaluable tool in maintaining happy and healthy pets. Stay turned for more pain awareness blogs all month long!